Motor Symptom Relief and Medication Reduction with Bilateral STN-DBS in Parkinson’s Disease: A Five-Year Experience from a Tertiary Neurosurgery Center
DOI:
https://doi.org/10.65761/pjcr.2024.1.1.13Keywords:
Parkinson’s disease, deep brain stimulation, STN-DBS, motor symptoms, medication reductionAbstract
To determine the effectiveness of bilateral Subthalamic Nucleus Deep Brain Simulation (DBS) on relieving motor symptoms and reducing the use of medication in patients with Parkinson’s disease (PD) in this country setting. This cohort study was carried out in the Department of Neurosurgery at the Punjab Institute of Neurosciences, Lahore, between January 2018 and January 2023. Seventy-three patients who received bilateral STN-DBS and fulfilled the required criteria were part of the study. Participants were interviewed and clinical data were also collected. The key results were changes in LEDD and in motor function, as measured by the UPDRS parts III and IV. Analysis was run using data to measure if using STN-DBS lessened the amount of medicine patients took and improved their motor symptoms. As a result of bilateral STN-DBS, there was a significant decrease in LEDD by 55.03% (p < 0.0001) and a large improvement in UPDRS-III scores by 80.49% (p < 0.0001). Despite the UPDRS-IV not improving much by 1% and not being significant statistically (p = 0.2751), the reduction in time with dyskinesia (17.54%) and off periods (22.44%) was visible, suggesting that motor complications were better controlled. Fitted with bilateral STN-DBS, many patients with early- to moderate-stage Parkinson’s disease get good results in countries where resources are scarce. Many people require less Dopamine-based medication and their symptoms of rigidity, tremors and Bradykinesia are greatly reduced. The results back up using STN-DBS as a routine treatment for people with PD in developing countries, helping to raise their well-being and treatment outcomes.
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