Current Evidence on Telerehabilitation for Amyotrophic Lateral Sclerosis: A Scoping Review of Physical Function and Functional Outcomes
DOI:
https://doi.org/10.65761/pjcr.2026.3.1.32Keywords:
Amyotrophic Lateral Sclerosis, Telerehabilitation, Telemedicine, Physical Therapy Modalities, Activities of Daily LivingAbstract
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder associated with declining physical function, respiratory impairment, and increasing rehabilitation needs. Telerehabilitation has emerged as an innovative approach to improve access to rehabilitation services while overcoming mobility-related barriers. This scoping review synthesized current evidence regarding the effects of telerehabilitation on physical function and functional outcomes in patients with ALS.
Methods: A scoping review was conducted in accordance with PRISMA-ScR guidelines using PubMed, Scopus, Web of Science, and ProQuest databases. Studies evaluating telerehabilitation interventions targeting physical and functional outcomes in ALS were included. Data were extracted and narratively synthesized across thematic domains, including physical function, activities of daily living, feasibility, adherence, safety, and patient satisfaction.
Results: Eight studies involving 146 participants met the eligibility criteria. Interventions included aerobic exercise, inspiratory and expiratory respiratory muscle training, stretching exercises, comprehensive physical therapy, and multidisciplinary home-based rehabilitation delivered through synchronous and asynchronous telehealth platforms. High adherence rates (81.5%–127%) and low attrition were consistently reported. Respiratory interventions demonstrated significant improvements in inspiratory and expiratory muscle strength, whereas several studies reported stabilization of functional decline and preservation of activities of daily living. Patient satisfaction was uniformly favorable despite occasional technological limitations affecting intervention delivery.
Conclusion: Telerehabilitation appears to be a feasible, safe, and clinically valuable strategy for maintaining functional outcomes in ALS. Future large-scale randomized studies are warranted to establish standardized intervention protocols, evaluate long-term clinical effectiveness, and optimize telehealth implementation across diverse healthcare settings.
References
1.De Marchi F, Sgarlata E, De Martino L, et al. Telemedicine in amyotrophic lateral sclerosis during COVID-19. Amyotroph Lateral Scler Frontotemporal Degener. 2021;22(5-6):386-393. DOI: 10.1080/21678421.2021.1904253
2. Andersen UT, Grönberg JB, Poulsen I, et al. Feasibility and safety of home-based high-intensity interval training in patients with amyotrophic lateral sclerosis: a pilot study. NeuroRehabilitation. 2024;54(1):89-98. DOI: 10.3233/NRE-230198
3. Helleman J, Kruitwagen ET, van den Berg LH, et al. Retrospective evaluation of a multidisciplinary e-health service for personalized ALS care. Amyotroph Lateral Scler Frontotemporal Degener. 2022;23(7-8):541-549. DOI: 10.1080/21678421.2022.2033345
4. Vicente-Campos D, et al. Inspiratory muscle training via telehealth in amyotrophic lateral sclerosis: a randomized case-control study. J Clin Med. 2022;11(14):4051. DOI: 10.3390/jcm11144051
5. Sreedharan S, et al. Feasibility of tele-rehabilitation for motor neuron disease in low-resource settings. Neurol India. 2021;69(4):945-951. DOI: 10.4103/0028-3886.325350
6. Rathore FA, et al. Telerehabilitation for neuromuscular disorders during the COVID-19 pandemic in Pakistan. J Pak Med Assoc. 2021;71(Suppl 8):S112-S116. DOI: 10.47391/JPMA.21-11
7. Hobson EV, Baird WO, Bradburn M, et al. Using technology to improve MDT outpatient care for people with ALS (the TiM study): a randomized controlled trial. Amyotroph Lateral Scler Frontotemporal Degener. 2024;25(1-2):12-21. DOI: 10.1080/21678421.2023.2262799
8. Helleman J, et al. Home monitoring and personalized feedback for patients with amyotrophic lateral sclerosis. J Med Internet Res. 2021;23(6):e25416. DOI: 10.2196/25416
9. Pulley M, Shafi MQ, Gelineau-Morel R, et al. Telehealth in the multidisciplinary care of ALS: patient and caregiver perspectives. Amyotroph Lateral Scler Frontotemporal Degener. 2022;23(5-6):415-422. DOI: 10.1080/21678421.2021.2014815
10. Hobson EV, et al. Using telehealth to support multidisciplinary care for ALS: the TiM system. Amyotroph Lateral Scler Frontotemporal Degener. 2021;22(3-4):230-239. DOI: 10.1080/21678421.2020.1831580
11. Paganoni S, et al. Remote assessment of physical function in ALS clinical trials. Amyotroph Lateral Scler Frontotemporal Degener. 2021;22(1-2):112-118. DOI: 10.1080/21678421.2020.1795101
12. Geronimo A, et al. Feasibility of a customized telemedicine platform for ALS. Telemed J E Health. 2022;28(3):395-403. DOI: 10.1089/tmj.2021.0112
13. Van Eijk RPA, et al. Monitoring ALS disease progression at home: a validation study of digital endpoints. J Neurol. 2021;268(11):4255-4264. DOI: 10.1007/s00415-021-10551-x
14. van Eijk RPA, de Jong YT, Bunte TL, et al. Digital self-monitoring of ALS: safety, feasibility, and clinical value. J Med Internet Res. 2022;24(2):e32150. DOI: 10.2196/32150
15. Cesarini S, Spataro R, La Bella V. Impact of telemedicine on quality of life and psychological distress in patients with amyotrophic lateral sclerosis and their caregivers. Front Neurol. 2023;14:1102451. DOI: 10.3389/fneur.2023.1102451
16. Pinto S, de Carvalho M. Telemonitoring of ALS patients on noninvasive ventilation: a randomized controlled trial. Amyotroph Lateral Scler Frontotemporal Degener. 2022;23(3-4):205-212. DOI: 10.1080/21678421.2021.1962358
17. Crockford C, et al. Cognitive and behavioral telehealth assessments in ALS. J Neurol Neurosurg Psychiatry. 2021;92(8):884-891. DOI: 10.1136/jnnp-2020-325510
18. Mioshi E, Caga J, Lillo P, et al. Telehealth-delivered support for caregivers of patients with ALS: a feasibility study. Dement Geriatr Cogn Disord. 2022;51(2):141-148. DOI: 10.1159/000524102
19. Karam CY, et al. Telehealth in neuromuscular medicine: post-pandemic perspectives. Muscle Nerve. 2022;66(1):12-21. DOI: 10.1002/mus.27546
20. Paganoni S, Bettencourt A, Davenport K, et al. Telehealth utilization and satisfaction among physical therapists in ALS clinical care. Arch Phys Med Rehabil. 2023;104(5):712-718. DOI: 10.1016/j.apmr.2022.11.015
21. Devenney EM, Kiernan MC, Lokesh A, et al. Feasibility and safety of remote trial visits in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2023;24(5-6):432-440. DOI: 10.1080/21678421.2023.2188204
22. Vasta R, et al. Telemedicine for ALS in Italy: a nationwide survey during and after pandemic. Neurol Sci. 2023;44(6):2045-2051. DOI: 10.1007/s10072-023-06692-y
23. Goyal NA, et al. Validation of remote ALSFRS-R assessments via telemedicine. Amyotroph Lateral Scler Frontotemporal Degener. 2023;24(1-2):55-62. DOI: 10.1080/21678421.2022.2114408
24. Groninger H, Phillips S, Robinson S, et al. Best practice guidelines for telehealth delivery of palliative care in amyotrophic lateral sclerosis. J Palliat Med. 2024;27(3):315-322. DOI: 10.1089/jpm.2023.0412
25. Chio A, Vasta R, Moglia C, et al. Italian recommendations for the use of telemedicine in ALS clinical practice. Neurol Sci. 2024;45(2):625-633. DOI: 10.1007/s10072-023-07158-x
26. Rutkove SB, Narayanaswami P, Morton JN, et al. Handheld electrical impedance myography for home-based monitoring of ALS progression. Muscle Nerve. 2024;69(2):188-195. DOI: 10.1002/mus.27998
27. Fournier RG, Goutman SA, Johnston WC, et al. Telemedicine utilization is associated with improved survival and retention in multidisciplinary ALS clinics. Neurology. 2024;102(2):e208014. DOI: 10.1212/WNL.0000000000208014
28. Spathis A, Booth S, Gardner J, et al. Feasibility of a patient-led home respiratory monitoring protocol in motor neuron disease. Amyotroph Lateral Scler Frontotemporal Degener. 2025;26(1-2):85-93. DOI: 10.1080/21678421.2024.2381254
29. Morita T, Nakamura Y, Hasegawa K, et al. Long-term safety and utility of telerehabilitation for patients with motor neuron disease in Japan: a prospective cohort study. J Neurol Sci. 2025;460:122045. DOI: 10.1016/j.jns.2024.122045
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