Association between Musculoskeletal Pain and Gastrointestinal Symptoms among Medical Students in Peshawar: A Cross-Sectional Study
DOI:
https://doi.org/10.65761/pjcr.2025.2.2.26Keywords:
Musculoskeletal Pain, Gastrointestinal Diseases, Medical Students, Low Back Pain, Sedentary Behavior, PakistanAbstract
Background: Musculoskeletal pain (MSP) is a leading cause of disability worldwide and is increasingly recognized among medical students. Prolonged sitting, intensive study hours, and poor posture place students at heightened risk of lower back, neck, and shoulder pain. Emerging evidence also suggests a link between sedentary behavior and gastrointestinal (GI) symptoms, yet data from Peshawar, Pakistan, remain scarce. This study aimed to estimate the prevalence and severity of MSP and GI symptoms among medical students and examine their association.
Methods: Research was a multi-center cross-sectional study on 346 undergraduate students in three medical colleges in Peshawar. A structured questionnaire was administered to participants, and it included the Visual Analog Scale (VAS) of back pain, The Modified Nordic Musculoskeletal Questionnaire of musculoskeletal fatigue, and self-report GI symptom scale. Cronbach alpha was used to verify reliability by adjusting it to 0.70 or above. Means and standard deviations (means) or frequencies (percentages) were used to explain descriptive statistics and chi-square, t-tests, and binary logistic regression tests were used to determine associations. Any value that was below 0.05 was counted as significant.
Findings: Mean age was 22.5 ± 2.1 years; 56.1% were female. Based on VAS, 39.9% (95% CI: 34.7–45.2) reported mild, 45.1% (95% CI: 39.8–50.4) moderate, and 15.0% (95% CI: 11.3–18.7) severe back pain. Musculoskeletal fatigue was most frequent in the lower back (67.9%; 95% CI: 62.9–72.9), shoulders (41.9%; 95% CI: 36.7–47.2), and legs (35.0%; 95% CI: 30.0–40.0). Overall, 45.1% (95% CI: 39.8–50.4) reported at least one GI symptom, most commonly bloating (30.1%; 95% CI: 25.3–35.0), constipation (25.1%; 95% CI: 20.6–29.6), and indigestion (22.0%; 95% CI: 17.6–26.4). Students with severe back pain (VAS 7–10) had higher odds of reporting GI symptoms than those with mild/moderate pain (OR = 2.1; 95% CI: 1.4–3.1; p = 0.002).
Conclusion: Medical students in Peshawar exhibit a high burden of MSP and GI symptoms, particularly in the lower back, shoulders, and legs. Severe back pain is significantly associated with digestive complaints, suggesting that prolonged sitting and sedentary behaviors contribute to both musculoskeletal and gastrointestinal morbidity. Integrated wellness strategies—including ergonomic interventions, physical activity promotion, movement breaks, and stress management—are recommended to mitigate these coexisting health issues.
References
1. Abdulghani HM, Marwa K, Alghamdi NA, Almasoud RN, Faraj AT, Alshuraimi AF, et al. Prevalence of the medical student syndrome among health professions students and its effects on their academic performance. Medicine (Baltimore). 2023;102(43):e35594. https://doi.org/10.1097/MD.0000000000035594
2. Algabbani MF. Prevalence of musculoskeletal pain among architecture undergraduates students: A cross-sectional study. Work. 2024;78(3):841-7. https://doi.org/10.3233/WOR-230459
3. Alshuweihi HH, Zadeh SAM, Al-Sharman A, Nambi G, Azab AR, Elsayed SH, et al. Prevalence and risk factors associated with work-related musculoskeletal disorders among physiotherapists in United Arab Emirates. Sci Rep. 2025;15(1):38878. https://doi.org/10.1038/s41598-025-22619-6
4. Althomali OW, Amin J, Alghamdi W, Shaik DH. Prevalence and factors associated with musculoskeletal disorders among secondary schoolteachers in Hail, Saudi Arabia: a cross-sectional survey. Int J Environ Res Public Health. 2021;18(12):6632. https://doi.org/10.3390/ijerph18126632
5. Behera P, Majumdar A, Verma M, Kumarasamy A, Mishra N. Musculoskeletal pain affecting undergraduate nursing students: A cross sectional study on the prevalence and the associated factors. J Prof Nurs. 2023;49:135-44. https://doi.org/10.1016/j.profnurs.2023.09.012
6. Casini I, Massai L, Solomita E, Ortenzi K, Pieretti S, Aloisi AM. Gastrointestinal Conditions Affect Chronic Pain and Quality of Life in Women. Int J Environ Res Public Health. 2024;21(11):1435. https://doi.org/10.3390/ijerph21111435
7. Duan C, Chen C, Ouyang Z, Duan C, Zhang S, Shang H, et al. Association of stress and functional gastrointestinal disorders in high school graduates. J Affect Disord. 2021;292:305-10. https://doi.org/10.1016/j.jad.2021.05.072
8. Felemban RA, Sofi RA, Alhebshi SA, Alharbi SG, Farsi NJ, Abduljabbar FH, et al. Prevalence and predictors of musculoskeletal pain among undergraduate students at a dental school in Saudi Arabia. Clin Cosmet Investig Dent. 2021:39-46. https://doi.org/10.2147/CCIDE.S292970
9. Guduru RKR, Domeika A, Obcarskas L, Ylaite B. The ergonomic association between shoulder, neck/head disorders and sedentary activity: A systematic review. J Healthc Eng. 2022;2022(1):5178333. https://doi.org/10.1155/2022/5178333
10. Javed S, Dawood MH, Memon MW, Selod IZ, Seja A. Prevalence of low back pain among medical doctors of the teaching hospitals in Karachi, Pakistan: A cross-sectional survey. SAGE Open Med. 2023;11:20503121231157217. https://doi.org/10.1177/20503121231157217
11. Kandasamy G, Almanasef M, Almeleebia T, Orayj K, Shorog E, Alshahrani AM, et al. Prevalence of musculoskeletal pain among undergraduate students. Front Med (Lausanne). 2024;11:1403267. https://doi.org/10.3389/fmed.2024.1403267
12. Keefer L, Bedell A, Norton C, Hart AL. How should pain, fatigue, and emotional wellness be incorporated into treatment goals for optimal management of inflammatory bowel disease? Gastroenterology. 2022;162(5):1439-51. https://doi.org/10.1053/j.gastro.2021.08.060
13. Li W, Gillies RM, Liu C, Wu C, Chen J, Zhang X, et al. Specialty preferences of studying-abroad medical students from low-and middle-income countries. BMC Med Educ. 2023;23(1):158. https://doi.org/10.1186/s12909-023-04123-5
14. Lu S, Zhu Y, Cui M, Guo Z, Li X, Song Y. Sedentary leisure behaviour, physical activity, and gastroesophageal reflux disease: Evidence from a Mendelian Randomization analysis. Health Sci Rep. 2025;8(3):e70479. https://doi.org/10.1002/hsr2.70479
15. Midenfjord I, Grinsvall C, Koj P, Carnerup I, Törnblom H, Simren M. Central sensitization and severity of gastrointestinal symptoms in irritable bowel syndrome, chronic pain syndromes, and inflammatory bowel disease. Neurogastroenterol Motil. 2021;33(12):e14156. https://doi.org/10.1111/nmo.14156
16. Nolan AJ, Govers ME, Oliver ML. Effect of fatigue on muscle latency, muscle activation and perceived discomfort when exposed to whole-body vibration. Ergonomics. 2021;64(10):1281-96. https://doi.org/10.1080/00140139.2021.1909146
17. Pacheco-Carroza E. Visceral pain, mechanisms, and implications in musculoskeletal clinical practice. Med Hypotheses. 2021;153:110624. https://doi.org/10.1016/j.mehy.2021.110624
18. Parto DN, Wong AY, Macedo L. Prevalence of musculoskeletal disorders and associated risk factors in canadian university students. BMC Musculoskelet Disord. 2023;24(1):501. https://doi.org/10.1186/s12891-023-06630-4
19. Torbey A, Kadri SA, Asaad SA, Zahrawi H, Alhouri A, Harba G, et al. Studying the prevalence of musculoskeletal pain among a sample of medical students in Damascus, Syria. A cross‐sectional study. Health Sci Rep. 2023;6(3):e1149. https://doi.org/10.1002/hsr2.1149
20. Verdú E, Homs J, Boadas-Vaello P. Physiological changes and pathological pain associated with sedentary lifestyle-induced body systems fat accumulation and their modulation by physical exercise. Int J Environ Res Public Health. 2021;18(24):13333. https://doi.org/10.3390/ijerph182413333
21. Vosoughi S, Niazi P, Abolghasemi J, Sadeghi-Yarandi M. The relationship between the level of postural stress, Musculoskeletal Disorders, and chronic fatigue: A case study in the dairy industry. Work. 2024;78(3):771-81. https://doi.org/10.3233/WOR-230309
22. Wang A, Zhou Y, Li X, Wang W, Zhao X, Chen P, et al. Investigating and analyzing the current situation and factors influencing chronic neck, shoulder, and lumbar back pain among medical personnel after the epidemic. BMC Musculoskelet Disord. 2024;25(1):316. https://doi.org/10.1186/s12891-024-07425-x
23. Wang W, Yan Y, Guo Z, Hou H, Garcia M, Tan X, et al. All around suboptimal health—a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and Personalised Medicine. EPMA J. 2021;12(4):403-33. https://doi.org/10.1007/s13167-021-00253-2
24. Wu YR, Tan ZB, Lu Y, Liu C, Dong WG. Physical activity, sedentary behavior, and the risk of functional gastrointestinal disorders: A two‐sample Mendelian randomization study. J Dig Dis. 2024;25(4):248-54. https://doi.org/10.1111/1751-2980.13274
25. Μangoulia P, Kanellopoulou A, Manta G, Chrysochoou G, Dimitriou E, Kalogerakou T, et al., editors. Exploring the Levels of Stress, Anxiety, Depression, Resilience, Hope, and Spiritual Well-Being Among Greek Dentistry and Nursing Students in Response to Academic Responsibilities Two Years After the COVID-19 Pandemic. Healthcare(Basel).2024;12(1):54. https://doi.org/10.3390/healthcare13010054
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Syed Waqas Arshad, Luqman Khan, Hasnain Iqbal, Sujjad Khan (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.
